By Amos Pines MD (auth.), Henry G. Burger (eds.)
Sex Hormone substitute Therapy addresses very important concerns in modern endocrinology. Its significant emphasis is at the results of the menopause and on androgen deficiency within the absence of overt disorder of the hypothalamus and/or pituitary in males. using hormone remedy for the first prevention of heart problems in post-menopausal girls has develop into a space of significant debate, and the professionals and cons are tested intimately. Secondary prevention additionally is still arguable and is addressed during this quantity.
a topic of specific difficulty is the therapy of estrogen deficiency indicators in ladies with the analysis of breast melanoma. no matter if older males with a few androgen deficiency signs and equivocally low plasma testosterone concentrations can be handled with androgens can be an issue of significant debate, as is the efficacy and safeguard of plant estrogens within the therapy of menopause-related complaints.
Sex Hormone substitute Therapy might be of curiosity to scholars and non-specialists, in addition to quite a lot of clinical practitioners together with endocrinologists, gynecologists, rheumatologists and cardiologists.
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Extra resources for Sex Hormone Replacement Therapy
Sample text
J Clin Endocrinol Metab 1996;81:3951-60. Berr C, Lafont S, Debuire B, Dartigues J-F, Baulieu E-E. Relationships of dehydroepi-androsterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: a French community-based study. Proc Nat! Acad Sci USA 1996;93:13410-5. Kalrnijn S, Launer U, Stolk RP, et al. A prospective study on cortisol, dehydroepiandrosterone sulfate, and cognitive function in the elderly. J Clin Endocrinol Metab 1998;83:3487-92. Barrett-Connor E, Edelstein SL.
Janowsky JS, Oviatt SK, Orwoll ES. Testosterone influences spatial cognition in older men. Behav Neurosci 1994;108:325-32. Sherwin BB. Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women. Psychoneuroendocrinology 1988;13:345-57. Barrett-Connor E, Goodman-Gruen D. Cognitive function and endogenous sex hormones in older women. J Am Geriatr Soc 1999;47: 1289-93. Gouras GK, Xu H, Gross RS, et al. Testosterone reduces neuronal secretion of Alzheimer's pamyloid peptides.
In the randomized, placebo controlled, double blind Postmenopausal EstrogenIProgestin Intervention Trial (PEPI) (17), 875 women received various estrogen/progestin regimens. Estrogen alone decreased LDL cholesterol levels and increased HDL cholesterol. Concomitant use ofmedroxyprogesterone acetate with estrogen blunted the increase in HDL cholesterol but did not affect the reduction in LDL cholesterol. Triglyceride levels increased with either therapy when compared with placebo. Micronized progesterone exerted less of a negative effect on HDL than medroxyprogesterone acetate (17).