By Walter Eckhart (auth.), Heinz Fraenkel-Conrat, Robert R. Wagner (eds.)
The time turns out ripe for a severe compendum of that phase of the organic universe we name viruses. Virology, as a technological know-how, having handed only in the near past via its descriptive section of naming and numbering, has most likely reached that degree at which quite few new-truly new-viruses could be chanced on. brought on through the highbrow probes and methods of molecular biology, genetics, biochemical cytology, and high-resolution microscopy and spectroscopy, the sector has skilled a real details explosion. Few critical makes an attempt were made to chronicle those occasions. This accomplished sequence, in order to contain a few 6000 pages in a complete of approximately 22 volumes, represents a dedication by means of a wide crew of lively investigators to research, digest, and expostulate at the nice mass of information in terms of viruses, a lot of that's now amorphous and disjointed, and scattered all through a large literature. during this means, we are hoping to put the full box in point of view, and to advance an invalua ble reference and sourcebook for researchers and scholars in any respect degrees. This sequence is designed as a continuum that may be entered anyplace, yet which additionally offers a logical development of constructing evidence and built-in concepts.
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USA 71:942. Brockman, W. , Lee, T. N. , 1975, Characterization of cloned evolutionary variants of simian virus 40, Cold Spring Harbor Symp. Quant. Bioi. 39:119. , 1975, Role of simian virus 40 gene A function in maintenance of transformation, J. 15:619. Butel, J. , Brugge, J. , and Noonan, C. , 1975, Transformation of primate and rodent cells by temperature-sensitive mutants of SV40, Cold Spring Harbor Symp. Quant. Bioi. 39:25. , Shenk, T. , 1975, Biochemical procedure for production of small deletions in simian virus 40 DNA, Proc.
M. , Griffin, B. , and Robberson, D. L. 1975, Polyoma virusA study of wild type, mutant and defective DNA's Cold Spring Harbor Symp. Quant. Bioi. 39:45. , 1974, Isolation and partial characterization of different defective DNA molecules derived from polyoma virus, J. Virol. 13:939. , 1975, Virion proteins of temperature-sensitive mutants of polyoma virus: Late mutants. Cold Spring Harbor Symp. Quant. Bioi. 39:243. , 1974, Polyoma virus proteins: A description of the structural proteins of the virion based on polyacrylamide gel electrophoresis and peptide analysis, Virology 62:319.
1973). , 1972; Pettersson, 1973). , 1973). , 1965). The viruses fall into similar subgroups when divided according to G + C content and nucleotide sequence homology. , types 1, 2, and 5), has a G + C content of 55-60% (Green, 1970; Piila and Green, 1965). It is also striking that between members of a subgroup the nucleotide sequences are up to 95% homologous, whereas DNA-DNA hybridizations between selected members of different subgroups show only about 10% homology (Green, 1970; Garon et al ..