Regulation and Genetics: Genetics of Animal Viruses by Walter Eckhart (auth.), Heinz Fraenkel-Conrat, Robert R.

By Walter Eckhart (auth.), Heinz Fraenkel-Conrat, Robert R. Wagner (eds.)

The time turns out ripe for a severe compendum of that phase of the organic universe we name viruses. Virology, as a technological know-how, having handed only in the near past via its descriptive section of naming and numbering, has most likely reached that degree at which quite few new-truly new-viruses could be chanced on. brought on through the highbrow probes and methods of molecular biology, genetics, biochemical cytology, and high-resolution microscopy and spectroscopy, the sector has skilled a real details explosion. Few critical makes an attempt were made to chronicle those occasions. This accomplished sequence, in order to contain a few 6000 pages in a complete of approximately 22 volumes, represents a dedication by means of a wide crew of lively investigators to research, digest, and expostulate at the nice mass of information in terms of viruses, a lot of that's now amorphous and disjointed, and scattered all through a large literature. during this means, we are hoping to put the full box in point of view, and to advance an invalua­ ble reference and sourcebook for researchers and scholars in any respect degrees. This sequence is designed as a continuum that may be entered anyplace, yet which additionally offers a logical development of constructing evidence and built-in concepts.

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USA 71:942. Brockman, W. , Lee, T. N. , 1975, Characterization of cloned evolutionary variants of simian virus 40, Cold Spring Harbor Symp. Quant. Bioi. 39:119. , 1975, Role of simian virus 40 gene A function in maintenance of transformation, J. 15:619. Butel, J. , Brugge, J. , and Noonan, C. , 1975, Transformation of primate and rodent cells by temperature-sensitive mutants of SV40, Cold Spring Harbor Symp. Quant. Bioi. 39:25. , Shenk, T. , 1975, Biochemical procedure for production of small deletions in simian virus 40 DNA, Proc.

M. , Griffin, B. , and Robberson, D. L. 1975, Polyoma virusA study of wild type, mutant and defective DNA's Cold Spring Harbor Symp. Quant. Bioi. 39:45. , 1974, Isolation and partial characterization of different defective DNA molecules derived from polyoma virus, J. Virol. 13:939. , 1975, Virion proteins of temperature-sensitive mutants of polyoma virus: Late mutants. Cold Spring Harbor Symp. Quant. Bioi. 39:243. , 1974, Polyoma virus proteins: A description of the structural proteins of the virion based on polyacrylamide gel electrophoresis and peptide analysis, Virology 62:319.

1973). , 1972; Pettersson, 1973). , 1973). , 1965). The viruses fall into similar subgroups when divided according to G + C content and nucleotide sequence homology. , types 1, 2, and 5), has a G + C content of 55-60% (Green, 1970; Piila and Green, 1965). It is also striking that between members of a subgroup the nucleotide sequences are up to 95% homologous, whereas DNA-DNA hybridizations between selected members of different subgroups show only about 10% homology (Green, 1970; Garon et al ..

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