Biochemistry & Genetics: Pretest Self-Assessment & Review by Golder Wilson

By Golder Wilson

PreTest is the nearest you will get to seeing the USMLE Step 1 earlier than you're taking it!

500 USMLE-style questions and answers!

Great for path evaluate and the USMLE Step 1, PreTest asks the appropriate questions so you’ll understand the perfect solutions. You’ll locate 500 clinical-vignette variety questions and solutions in addition to whole causes of right and fallacious solutions. The content material has been reviewed by way of scholars who lately handed their checks, so that you recognize you're learning the main proper and up to date fabric attainable. No different learn consultant pursuits what you really want to grasp which will move like PreTest!

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32. The answer is b. (Murray, pp 412–434. Scriver, pp 3–45. Sack, pp 3–29. ) A special DNA polymerase called telomerase is responsible for replication of the telomeric DNA. Telomerase contains an RNA molecule that guides the synthesis of complementary DNA. Telomerase is therefore an RNA-dependent DNA polymerase in a category with reverse transcriptase. Telomerase does not require an RNA primer, initiating synthesis of the leading strands at 3′ ends within the telomeric DNA. Synthesis of the lagging strands uses primase, DNA polymerase III, and DNA polymerase I, as with the replication of other chromosomal regions.

In all of the forms of DNA repair in normal cells, a common sequence of events occurs. 1. The single or multiple base abnormality is surveyed and detected by a specific protein or proteins. 2. The DNA is nicked on one side of the damaged DNA. 3. A specific enzyme excises the damaged portion (steps 2 and 3 can be combined if an excinuclease cuts on both sides of the damaged DNA). 4. The damaged portion of the strand is replaced by resynthesis catalyzed by DNA polymerase I. 5. A ligase seals the final gap.

Three codons are reserved as “stop” signals that result in peptide chain termination. The linear correspondence of codons in DNA and of amino acids in protein domains is interrupted by the presence of introns in DNA. Codons differ from the dinucleotide tandem repeats that provide useful DNA polymorphisms, or the trinucleotide repeats that can be responsible for disease. The genetic code is universal in the sense that codon–amino acid relationships are the same in all organisms. The genetic code (codon assignments in messenger RNA.

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