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Additional resources for Biochemistry and Genetics Pretest Self-Assessment and Review
The CAC is amphibolic, involved in catabolism to yield ATP energy and anabolism through gluconeogenesis and fatty acid synthesis. • The CAC is under respiratory control, being tightly coupled to ox-phos by levels of oxidized cofactors (such as NAD+) and by end-product inhibition of PDH (acetyl-CoA, NADH). Key concepts: Glycogen metabolism and gluconeogenesis (Murray, pp 178-190. ) • Glycogen is stored glucose in the form of a branched polysaccharide analogous to starch in plants; it accounts for 6% of liver mass and 1% of muscle mass in fed states.
3. GENOME Key concepts: DNA structure (Murray, pp 343-353. Scriver, pp 3-45. ) • Deoxyribonucleic acid (DNA) is the chemical basis of genes and chromosomes, its structure providing information for cell division, embryogenesis, and heredity. Changes in DNA structure cause human variation and genetic disease, providing the basis for DNA diagnosis. • Each DNA strand is a sequence of the GATC deoxyribonucleotide units shown in Fig. 13A; the DNA strands are directional and are diagrammed with the free triphosphate of the 5′-sugar-carbon (5′-end) at the left and the 3′-end to the right (Fig.
LIPID, AMINO ACID, AND NUCLEOTIDE METABOLISM Key concepts: Significant lipids and lipid synthesis (Murray, pp 140-150, 216-228. ) • Lipids, including fats, oils, steroids, and waxes, are related by their insolubility in water and function in energy storage, membrane barriers, and neural insulation. • Simple lipids are fatty acids linked with alcohols to form esters, including fats (solid glycerol esters), oils (liquid glycerol esters), and waxes (fatty acids linked to long-chain alcohols). • Complex lipids include links to phosphoric acid (phospholipids), the 18-carbon amino alcohol sphingosine (sphingophospholipids), carbohydrate (glycosphingolipids), and proteins (including lipoproteins).