By J. Bernués, F. Azorín (auth.), Prof. Dr. Fritz Eckstein, Prof. Dr. David M. J. Lilley (eds.)
Molecular biology is likely one of the such a lot speedily constructing and whilst most fun disciplines. the major to molecular biology lies within the realizing of nucleic acids - their constitution, functionality, and interplay with proteins.
Nucleic Acids and Molecular Biology retains scientists knowledgeable of the explosively becoming info and complies with the good curiosity during this box by means of providing a endured excessive common of evaluation. a considerable a part of this quantity has been dedicated to the research of other facets of nucleic acid-protein-interactions together with RNA-protein-interaction.
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Example text
4) (Hayes et al. 1990). The periodicity of hydroxyl radical cleavage reflects a narrowing of the minor groove of DNA every 10-11 bp, and is indicative of an intrinsic curvature or directional flexibility within the structure of 5S DNA (Burkhoff and Tullius 1987; Hayes et al. 1990). Since DNA has to be drastically bent around the histone core, it is likely that sequence-directed positioning of nucleosomes is favored by such curvature or flexibility. The exact nucleosome position is determined by adjustment of histone-DNA interactions such that the smallest amount of energy is expended in wrapping a given DNA sequence around the histone core (Drew and Travers 1985; Jayasena and Behe 1989; Shrader and Crothers 1989; Simpson 1991).
Proc Natl Acad Sci USA 91:5913-5917 Pruss D, Hayes 11, Wolffe AP (1994b) Nucleosomal anatomy - implications for chromatin structure and function. BioEssays (in press) Rhodes D (1985) Structural analysis of a triple complex between the histone octamer, a Xenopus gene for 5S RNA and transcription factor IlIA. EMBO J 4:3473-3482 Richard-Foy H, Hager GL (1987) Sequence-specific positioning of nucleosomes over the steroid-inducible MMTV promoter. EMBO J 6:2321-2328 Richmond TJ, Finch JT, Rushton B, Rhodes D, Klug A (1984) Structure of the nucleosome core particle at 7 A resolution.
This initiates a process that relieves nucleosome-mediated repression and thus makes available additional cis-acting DNA elements to the basal transcriptional machinery (Archer et al. 1992). ~ Fig. 2. Chromatin structural changes upon induction in the PHOS promoter. Accessible linker regions between positioned nucleosomes are indicated. The strategically positioned PH04 binding site (filled box) between nucleosomes-2 and-3 is indicated by an asterisk. Other trans-acting factor binding sites important for subsequent activation are indicated by open triangles .