By Thomas Klockgether
This well timed reference provides, for the 1st time, new findings in molecular genetics which are appropriate to the epidemiology, pathogenesis, neuropathology, scientific gains, and administration of ataxia-bridging the distance among medical and scientific perform. geared up by means of the unique ataxia issues, their pathogenesis, and management-facilitating quickly and effective diagnoses! delivering complementary sections at the anatomy of the spinocerebellar process, its common functionality, and a historical past of ataxia study and administration, the guide of Ataxia problems ·clarifies the impression of deciding on the molecular reasons of ataxia ·offers in-depth research of dominant and recessive and nonhereditary ataxia issues ·explores the very important connection among the genotypes and phenotypes of assorted degenerative ataxia issues ·and extra! Written via greater than 60 overseas specialists and supplemented with over 2600 literature references, pictures, micrographs, drawings, and tables, the guide of Ataxia problems is a vital and precious reference for medical neurologists and neuropathologists, neuropediatricians, geneticists, physiatrists, and clinical university scholars in those disciplines.
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Extra resources for Handbook of Ataxia Disorders (Neurological Disease and Therapy)
Example text
Close to the glomeruli, olivary dendrites show numerous varicosities that contain membranous cisternae, the lamellar bodies. Their density correlates with the of level cerebellar input as well as with the level of synchronous activity within the IO. , 1995, 1997). The morphology of synaptic input to 1 0 neurons has been best studied for the direct cerebellar backprojection and the indirect loop through the mesodiencephalic nuclei. , 1988). The remaining terminals predominantly contact nonglomerular dendrites, with only very few contacts formed on somata and axons.
1990). Commonly, five to six dendritic spines, originating from different neurons, are clustered forming the core of a so-called glomerulus. Most, IO participate in the formation of the glomerular if not all, spines within the cores. , 1974). The number of neurons coupled by gap junctions has been estimatedby intracellular injection of Lucifer Yellow, 28 Sultan et al. a fluorescent dye able to permeate through gap junctions. Using this approach, it IO neurons are coupled in slices of guinea has been demonstrated that six to eight pig olivary glomeruli (Benardo and Forster, 1986).
1992a,b). D. TheSpinocerebellarTracts Besides the vestibular system, the spinocerebellar tracts provide the only direct i n f o ~ a t i o nfrom the periphery to the cerebellum. They convey signals from various peripheral proprio-, extero-, and enteroceptors. The afferents from the peripheral receptors contact neurons located on different levels within the spinal cord, including the dorsal column nuclei which, in turn, project as mossy fibers to the cerebellar cortex and deep cerebellar nuclei through the inferior or superior cerebellar peduncles (Yoss, 1952a,b).