By Jean Louis Guénet, Fernando Benavides, Jean-Jacques Panthier, Xavier Montagutelli
This publication, written by way of skilled geneticists, covers themes starting from the traditional historical past of the mouse species, its dealing with and replica within the laboratory, and its classical genetics and cytogenetics, to trendy concerns together with the research of the transcriptome, the parental imprinting and X-chromosome inactivation. The thoughts for growing every kind of mutations, both through genetic engineering or by utilizing mutagens, also are reviewed and mentioned intimately. eventually, a final bankruptcy outlines the method used for the research of complicated or quantitative traits.
The authors additionally talk about the significance of exact phenotyping, that's now played within the mouse clinics proven all over the world and determine the bounds of the mouse version, which below definite conditions can fail to provide the phenotype anticipated from the cognate situation within the human version. for every bankruptcy an updated checklist of pertinent references is supplied.
In brief, this publication bargains a vital source for all scientists who use or plan to take advantage of mice of their research.
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Additional resources for Genetics of the Mouse
Example text
IVF has the advantage that it can be performed using frozen or fresh sperm. The technique can also be used for the re-derivation of infected mouse colonies, and is frequently used for the transfer of genotypes of interest between laboratories. , when it produces viable oocytes) but is unable to breed because of some kind of handicap, an ovarian transplantation is a good option. Some classic mutant mice such as dystrophia muscularis (Lama2dy), obese (Lepob), and dwarf (Pou1f1dw) were historically maintained by performing serial ovary transplantation.
The corpora lutea secrete the hormone progesterone, the hormone of pregnancy, and persist until the end of pregnancy—if pregnancy ensues. If not, the corpora lutea degenerate and a new cycle starts. Corpora lutea are easy to recognize at the surface of the mouse ovary because they are slightly protuberant and often stained light orange. After fixation with formalin or Bouin’s fixative, their identification is even easier. When virgin or non-pregnant females are housed in groups and mated with males without prior selection of the phase of the estrous cycle, the frequency of natural mating is not evenly distributed over the following nights.
26 This definition was reconsidered when it was recognized that some proteins are not enzymes. W. L. Tatum were awarded the Nobel Prize in Physiology or Medicine in 1958 for their discovery of the “role of genes in regulating biochemical events within cells”. 3 Basic Notions of Genetics 35 motto was then changed to “one-gene-one-polypeptide” and the definition of the gene was modified accordingly. In 2002, once the sequencing of the mouse nuclear DNA was completed, followed by the extensive analysis of the transcriptome27 and the confirmation that a great number of genes were not translated into polypeptides, the definition of the gene changed again.