By A. Houben
Reprint of: Cytogenetic and Genome study 2009, Vol. 124, No. 3-4 Our knowing of the functionality and constitution of chromosomes and their interrelationship has grown lately. The chapters during this factor describe the advances which were made attainable through combining microscope recommendations with subtle biochemical and genetic methods to release the secrets and techniques of chromosomes. The authors examine many elements of chromosome biology, akin to protein, DNA and RNA composition of chromosomes, outlined chromosome buildings, strange chromosome buildings and really expert chromosomes and microscope instruments for chromosome research. 'Chromosome constitution and serve as' could be a useful source for undergraduate and postgraduate scholars in fields equivalent to plant and animal sciences, genetics, and molecular biology. in reality, any pupil, instructor or researcher attracted to chromosome biology will locate this precise factor essential.
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Additional resources for Chromosome Structure and Function
Example text
Mercier R, Armstrong SJ, Horlow C, Jackson NP, Makaroff CA, et al: The meiotic protein SWI1 is required for axial element formation and recombination initiation in Arabidopsis. Development 130:3309–3318 (2003). Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J: Cloning and characterization of hCTF18, hCTF8, and hDCC1 – Human homologs of an Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. J Biol Chem 278: 30051–30056 (2003). Meyer BJ: X-Chromosome dosage compensation, in Girard LR (ed): WormBook, The C.
EMBO J 26: 4609–4618 (2007). Uhlmann F: Molecular biology: cohesin branches out. Nature 451:777–778 (2008). 214 Ünal E, Heidinger-Pauli JM, Kim W, Guacci V, Onn I, et al: A molecular determinant for the establishment of sister chromatid cohesion. Science 321:566–569 (2008). van Heemst D, Heyting C: Sister chromatid cohesion and recombination in meiosis. Chromosoma 109:10–26 (2000). Vass S, Cotterill S, Valdeolmillos AM, Barbero JL, Lin E, et al: Depletion of Drad21/Scc1 in Drosophila cells leads to instability of the cohesin complex and disruption of mitotic progression.
After degradation of its inhibitor securin, yeast separase cleaves most cohesins to separate chromatids during mitosis [Uhlmann, 2007]. In A. thaliana, the separase AESP is required for cohesin removal from meiotic chromosomes and is essential for embryo development [Liu and Makaroff, 2006]. Besides cohesin, SWI1 (Switch) with a partial similarity to SMC proteins is involved in sister chromatid cohesion and recombination during early male and female meiosis in A. , 2002; Boateng and Ma- Higher plants, as other eukaryotes, obviously form various SMC complexes that together with interacting proteins mediate dynamic chromosome architecture in meristematic and differentiated tissues.