By Steven L. Kunkel, Nuria Godessart, Cory Hogaboam, Stephen W. Chensue, Nicholas Lukacs (auth.), Kuldeep Neote, Gordon L. Letts, Bernhard Moser (eds.)
Chemokines play a major function in recruiting inflammatory cells into tissues in keeping with an infection and irritation. in addition they play a tremendous function in coordinating the stream of T-cells, B-cells and dentritic cells, essential to generate an immune reaction (response to harm, allergens, antigens, invading microorganisms). They selectively allure leukocytes to inflammatory foci, inducing either cellphone migration and activation. they're excited about quite a few illnesses, like atherosclerosis, lung and dermis irritation, a number of sclerosis, or HIV.
Volume 2 of this two-volume set discusses the pathophysiology of chemokines. it's divided into components: a) chemokines in animal illness versions, and b) chemokines as drug goals. including quantity 1, which discusses the immunobiology of chemokines, either volumes supply a accomplished assessment of chemokine biology.
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Additional resources for Chemokine Biology — Basic Research and Clinical Application: Volume II: Pathophysiology of Chemokines
J Immunol 165: 1102–1110 Christen U, McGavern DB, Luster AD, Von Herrath MG, Oldstone MB (2003) Among CXCR3 chemokines, IFN-gamma-inducible protein of 10 kDa (CXC chemokine ligand (CXCL) 10) but not monokine induced by IFN-gamma (CXCL9) imprints a pattern for the subsequent development of autoimmune disease. J Immunol 171: 6838–6845 Kim SH, Cleary MM, Fox HS, Chantry D, Sarvetnick N (2002) CCR4-bearing T cells participate in autoimmune diabetes. J Clin Invest 110: 1675–1686 Camacho SA, Heath WR, Carbone FR, Sarvetnick N, LeBon A, Karlsson L, Peterson PA, Webb SR (2001) A key role for ICAM-1 in generating effector cells mediating inflammatory responses.
Despite their usefulness in highlighting the involvement of rare chemokines in disease, the most useful data to date has come from studies on purified cell populations . , age, sex and anatomical site matched tissues from patients with known treatment history and comparable disease status. 46 Chemokines as drug targets Neutralizing antibodies Neutralization of MIP-1_ and MCP-1 reduced inflammation in a rat model of experimental allergic encephalitis (EAE, a model for multiple sclerosis) .
In situ hybridization showed that infiltrating mast cells were the predominant source of CCL4 and that the expression of CCL4 corresponded with the influx of CD4+ and CD8+ T cells into the draining lymph node [42, 43]. Neutralization of this chemokine during the sensitization phase inhibited CD4+ and CD8+ T cell trafficking into the draining lymph node and decreased delayed type hypersensitivity responses . Mast cells and basophils have also been shown to express CD40 ligand and induce IgE production in B cells in vitro [44, 45].