By Jesus Jimenez-Barbero, F. Javier Canada, Sonsoles Martin-Santamaria (eds.)
In fresh years there was expanding facts of the significance of carbohydrates and glycoconjugates in biomedical functions, and using man made ligands in accordance with carbohydrates as medicinal drugs has got a lot consciousness. Focussing on drug discovery from key ambitions and putting an emphasis at the multi-disciplinary methods essential to problem those concerns, this booklet comprehensively covers the recent and up to date discoveries within the zone of carbohydrate drug discovery.
Carbohydrates in Drug layout and Discovery is divided into 5 sections, starting with a creation and viewpoint at the present industry. The ebook then is going directly to speak about new artificial tools in glycobiology, using glycobiology in chemical biology and glycobiology in drug discovery.
Providing a world viewpoint in this wide region, and delivering examples of therapeutics already built utilizing those tools, this e-book presents a entire creation, dialogue and replace in this quickly constructing box for medicinal chemists and biochemists operating in and academia.
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Hsu and M. L. Lukic, Immunol. , 2012, 52, 100. 81. N. U. Jain, A. Venot, K. Umemoto, H. Leffler and J. H. , 2001, 10, 2393. 82. P. E. Johnson, E. Brun, L. F. MacKenzie, S. G. Withers and L. P. McIntosh, J. Mol. , 1999, 287, 609. 1 Introduction Perception of pathogens by their hosts is the outcome of a highly conserved and sophisticated defense system, tightly regulated by both pathogen and host signaling molecules exposed on their cell surfaces. 1 Molecular recognition studies of glycans at the host–pathogen surfaces are pivotal to deeply comprehend essential biological mechanisms and offer many possibilities to control disease states.
J. Reina, M. The A. Bernardi, J. Rojo and P. M. Nieto, Org. Biomol. , 2011, 9, 7705; ´paut, C. Guzzi, I. Sutkeviciute, S. Sattin, R. Ribeiro-Viana, (b) M. The N. Varga, E. Chabrol, J. Rojo, A. Bernardi, J. Angulo, P. M. Nieto and F. Fieschi, J. Am. Chem. , 2013, 135, 2518. 60. A. Canales, J. Angulo, R. Ojeda, M. Bruix, R. Fayos, R. Lozano, ´nez-Gallego, M. Martı´n-Lomas, P. M. Nieto and J. Jime ´nezG. Gime Barbero, J. Am. Chem. , 2005, 127, 5778. ¨lti, P. Egloff, 61. M. Schubert, S. Bleuler-Martinez, A.
J. E. Hudak and C. R. Bertozzi, Chem. , 2014, 21, 16. 3. (a) B. Meyer and T. Peters, Angew. , Int. , 2003, 42, 864–890; (b) A. C. Lepre, M. J. Moore and W. J. Peng, Chem. , 2004, 104, 3641–3675; (c) J. Angulo and P. M. Nieto, Eur. Biophys. , 2011, 40, 1357–1369; (d) L. P. Calle, F. J. Canada and J. Jimenez-Barbero, Nat. Prod. , 2011, 28, 1118–1125; (e) M. A. Johnson and B. M. Pinto, Carbohydr. , 2004, 339, 907–928; (f) A. Bhunia, S. Bhattacharjya and S. Chetterjee, Drug Discovery Today, 2012; (g) T.