By Arieh Warshel
This useful reference explores computing device modeling of enzyme reations--techniques that support chemists, biochemists and pharmaceutical researchers comprehend drug and enzyme motion.
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Additional resources for Computer modeling of chemical reactions in enzymes and solutions
Hydrazones have proven versatile functional groups in organic synthesis. 162 The ﬁrst use of a hydrazone in the capacity of a linker unit was done by Kamogawa et al. 8),163 and it represents an early example of simple diversity cleavage. Cleavage via simple reduction (NaBH4 or LiAlH4) or elimination (NaOCH2CH2OH) provided alkanes (21) or alkenes (22), respectively, while treatment with potassium cyanide resulted in the corresponding nitriles (23). 8. 8. Multifunctional cleavage from Kamogawa’s hydrazone linker.
For ester-linked substrates, Kurth et al. 76 In related work, Chandrasekhar et al. 2. 2. 2, Entry 14). 2 Cyclorelease Linker Units As described previously, cleavage of substrates from acid and base labile linker units can be readily achieved using mild conditions. However, a signiﬁcant drawback of such linker units, which has limited their application in more general organic synthesis, is that a common polar functional group is introduced into every target molecule in a compound library during cleavage.
10 L I N K E R S T R A T E G I E S I N M O D E R N SO LI D - P H A S E O R G A N I C S Y N T H E S I S linker unit can be achieved by treating with 50% TFA in DCM with addition of Et3SiH as a scavenger. Other linker units for amines have been developed based on supported aldehydes or diazonium salts. 53,63 The triazene linkage is stable against a range of reaction conditions but can be conveniently cleaved to release functionalized amines upon treatment with 10–50% TFA. Finally, linker units based on common protecting groups for carbonyl groups have also been adapted for use as linker units.