By Camille Georges Wermuth
The perform of Medicinal Chemistry fills a spot within the checklist of obtainable medicinal chemistry literature. it's a single-volume resource at the functional elements of medicinal chemistry. thought of ""the Bible"" via medicinal chemists, the ebook emphasizes the tools that chemists use to behavior their study and layout new drug entities. It serves as a realistic guide concerning the drug discovery strategy, from notion of the molecules to drug creation.
The first a part of the publication covers the historical past of the subject material, inclusive of the definition and background of medicinal chemistry, the dimension of organic actions, and the most stages of drug job. the second one a part of the ebook provides the line to studying a brand new lead compound and making a operating speculation. the most elements of the publication talk about the optimization of the lead compound when it comes to efficiency, selectivity, and safeguard.
The perform of Medicinal Chemistry could be thought of a ""first-read"" or ""bedside book"" for readers who're embarking on a profession in medicinal chemistry.
NEW TO THIS version:
* concentrate on chemoinformatics and drug discovery
* greater pedagogical features
* New chapters together with:
- Drug absorption and transport
- Multi-target drugs
* Updates on sizzling new components:
NEW! Drug discovery and the most recent techniques
NEW! How strength medications can go through the drug discovery/ improvement stages extra quickly
NEW! Chemoinformatics
Read or Download The Practice of Medicinal Chemistry, Third Edition PDF
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Additional info for The Practice of Medicinal Chemistry, Third Edition
Example text
Both of them discovered nitrogen as a constituent of air, carbon monoxide, ammonia, and several other gases ; manganese, barium and chlorine; isolated glycerin and many acids, including tartaric, lactic, uric, prussic, citric, and gallic. 3 He should be known as one of the most astonishing 18th century “men of the Enlightenment,” the founder of modern scientific CHAPTER 1 A History of Drug Discovery experimental methodology. By formulating the principle of the conservation of mass, he gave a clear differentiation between elements and compounds, something so important for pharmaceutical chemistry.
Further chapters discuss the optimization of lead compounds in terms of potency, selectivity, and safety; the contribution of genomics; molecular biology and X-ray crystallization to drug discovery and development, including the design of peptidomimetic drugs; and the development of drug-delivery systems, including organ targeting and the preparation of pharmaceutically acceptable salts. The final section covers legal and economic aspects of drug discovery and production, including drug sources, good manufacturing practices, drug nomenclature, patent protection, social-economic implications and the future of the pharmaceutical industry.
11 D-44227 Dortmund Germany xxxiii Contributors Camille G. Wermuth Prestwick Chemical Inc. Boulevard Gonthier d’Andernach 67400 Illkirch France Stefan Wetzel Max Planck Institute of Molecular Physiology Otto-Hahn-Str. 11 D-44227 Dortmund Germany Kenton H. Zavitz Myriad Genetics, Inc. 320 Wakara Way Salt Lake City, UT 84108 USA This page intentionally left blank Preface to the First Edition The role of chemistry in the manufacture of new drugs, and also of cosmetics and agrochemicals, is essential.