By James G. Fox, Stephen Barthold, Muriel Davisson, Christian E. Newcomer, Fred W. Quimby, Abigail Smith
Illnesses, the second one quantity within the 4 quantity set, The Mouse in Biomedical examine, departs from the 1st version, through discussing particular illness inflicting microorganisms, instead of the structure utilized in the 1st version which mentioned infectious ailments affecting particular organs and tissues. As such, the amount contains 26 chapters subdivided into RNA viruses and DNA viruses, in addition to bacterial, mycotic, and parasitic infections. those chapters not just offer updates on pathogenesis, epidemiology and prevention of formerly famous murine pathogens, but additionally contain details on newly well-known disease-causing organisms: mouse parvovirus, cilia linked respiration bacilli and Helicobacter spp. A separate classification, such as three chapters, discusses zoonoses, tumor pathology of genetically engineered mice, and spontaneous illnesses in known mouse lines.
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Additional info for The Mouse in Biomedical Research, Volume 2, Second Edition: Diseases (American College of Laboratory Animal Medicine)
Example text
Using PCR and in situ hybridization, MCMV was found in the brains, skin, and salivary glands of the fetuses. However, a recent study in which MCMV was inoculated intratesticularly found no evidence of virus transmission to fertilized oocytes, blastocysts, fetal tissues, or newborn animals following mating of infected males with uninfected females (Tebourbi et al. 2001). Nonetheless, despite the artificial nature of some of these studies, they show that the presence of MCMV in the genital tract at the time of embryonic implantation has the potential not only to initiate fetal infection but also to interfere with morphogenesis.
PATHOGENESIS Effect of Age, Dose, and Route of Inoculation immature mice than in adults. p. is approximately 2 pfu, using salivary gland virus. However, in adult BALB/c, the LD50 is approximately 5 × 104 pfu (Fitzgerald et al. 1990). The resistance of mice to lethal MCMV infection matures after weaning (Booss and Wheelock 1975; Selgrade and Osborn 1974) and continues to increase until around 8 weeks of age (G. R. Shellam, unpublished observation), after which it changes little until old age (Grundy (Chalmer) et al.
Cardiovascular Diseases MYOCARDITIS Viral infection has been recognized as one of the etiological agents of myocarditis in humans (Friman et al. 1995; Feldman and McNamara 2000), which may progress to dilated cardiomyopathy. This is a serious and often terminal condition (Friman and Fohlman 1997; Kawai 1999). Viruses commonly associated with myocarditis include the picornaviruses, particularly Coxsackie viruses, orthomyxoviruses, and herpesviruses (Friman et al. 1995; Huber 1997). HCMV infection has been associated with the development of myocarditis (Wink and Schmitz 1980; Cohen and Corey 1985); cytomegalic cells with intranuclear inclusions are found in the endothelium and myocardial cells in the hearts of infants and adults with generalized CMV disease (Ahvenainen 1952; Myerson et al.