Polymeric drugs and drug delivery systems by Richard L. Dunn, Raphael M. Ottenbrite

By Richard L. Dunn, Raphael M. Ottenbrite

Masking a wide spectrum of tools of drug supply and targeting using polymers and fabrics, this quantity provides new fabrics and strategies for managed drug free up. Emphasizing number of fabrics for drug supply instead of simply reviewing present equipment, the editors problem researchers to enterprise into new components and view new equipment. integrated is an exam of modern advances in biodegradable and bioerodible polymer matices for drug supply. An introductory element of 4 educational chapters ("Biologically lively Polymers", "Polymeric Matrices", "Liposomes", and "Interactions among Polymeric Drug supply structures and organic Systems") should be of serious price to these simply getting into the field.

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4) is observed as shown in Figure 8. 4. 0, (N,N-dimethylamino)ethyl groups of DMAEMA are fully ionized. An increasing electrostatic repulsion between charged sites on DMAEMA disrupts the hydrogen bonds between EAAm and DMAEMA. These interfere with the hydrophobic interactions between (N,N-dimethyl©2001 CRC Press LLC 03ch_Tech_Poly_183160 10/24/2000 7:45 AM Page 51 Figure 8 Permeation of hydrocortisone across the poly(DMAEMA-co-AAm) gel membrane in response to pulsatile temperature change. amino)ethyl groups above the LCST and the hydrophobic contribution to the LCST due to hydrogen bonding.

First, the isotactic chain has no intrachain hydrogen bonds linking its ester side chains. On the other hand, every sequence in the syndiotactic chains bring two pendant hydroxy groups into close proximity where they can form a hydrogen bond that stabilizes the local chain conformation. These differences in stereochemical configuration can lead to the significant change in physical properties. Therefore, polyDMAEMA with syndiotatic triads has stable intramolecular interaction that is more favorable for the temperature-induced phase transition ©2001 CRC Press LLC 03ch_Tech_Poly_183160 10/24/2000 7:45 AM Page 48 Figure 5 α-CH3 portion of the 13C-NMR spectra of poly DMAEMA; (a) prepared in water/ethanol, (b) prepared in water.

In order to assay cytotoxicity of the free ADR or micelles loaded with ADR, culture medium was replaced with 10% FBS-supplemented phenol red-free DMEM containing 10% alamar Blue, a dye that is subject to reduction by cytochrome c activity and changes the color from blue to red [38]. After 4-hour incubation, reduction of the dye was estimated by absorbance at 560 and 600 nm. PIPAAm-PBMA polymeric micelles loaded with ADR showed higher cytotoxic activity than that of free ADR at 37°C (above the LCST) ©2001 CRC Press LLC 02ch_Tech_Poly_183160 10/24/2000 7:39 AM Page 33 Figure 5 On–off switched drug (ADR) release from PIPAAm-PBMA micelles containing ADR responding temperature changes.

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