By Bernard Lerer
This ebook presents a conceptual framework for figuring out and learning the pharmacogenetics of psychotropic medications, studies advances within the box, and describes the findings that experience already emerged. assurance extends to antipsychotics, antidepressants and temper stabilizing, cognitive-enhancing and anxiolytic medications. the quantity additionally examines the interface of pharmacogenetics with substance dependence and mind imaging, and considers its effect at the biotechnology and pharmaceutical industries. This publication defines the younger box of pharmacogenetics because it applies to psychotropic medications, and is consequently a necessary reference for all clinicians and researchers concerned.
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Extra resources for Pharmacogenetics of Psychotropic Drugs
Example text
Taken together, these data suggest that rational candidate gene selection for psychiatric pharmacogenetic studies can be accomplished based upon biological data. Therefore, the establishment of extreme thresholds to achieve significance may result in inflated type II errors rates and minimize the opportunity to take advantage of the genomic information being generated by the Human Genome Project and other large-scale sequencing efforts. A second important consideration in evaluating case-control association studies is the criteria used to select a candidate polymorphism within the gene of interest.
1996) can be utilized to detect new variants. However, since most genes contain a number of sequence variants including single nucleotide polymorphisms (SNPs), the selection of which variant or variants to genotype in a case-control association study may be critical. Several issues should be considered. First, the frequency of the rare allele of a variant may be important. Variants with low frequencies of the rare allele may provide little power to detect significant associations unless the study group size is large or the variant has a strong influence on the phenotype.
K. Malhotra sequence variants are synonymous substitutions that do not alter the amino acid sequence of the gene product. ” Positive findings with nonfunctional markers are more likely to be secondary to chance or to inadvertent ethnic stratification of cases and controls. The nonfunctional or silent variant may be in linkage disequilibrium (nonrandom population association) with an as yet undiscovered functional variant. However, a difference in the frequency of a silent variant and the functional variant to which it is linked dilutes the information content of the silent variant.