Myeloproliferative Neoplasms: Biology and Therapy by Carlos E. Bueso-Ramos, James W. Vardiman (auth.), Srdan

By Carlos E. Bueso-Ramos, James W. Vardiman (auth.), Srdan Verstovsek, Ayalew Tefferi (eds.)

This succinct source presents an excellent stability of the biology and useful healing recommendations for traditional and non-classic BCR-ABL-negative myeloproliferative neoplasms. using present global health and wellbeing association nomenclature, type, and diagnostic standards, overseas specialists have assembled to show the main updated wisdom during this speedily evolving box. the hole chapters hide the prognosis and class, genetics, cytogenetic findings, and prognostic elements of MPNs. extra chapters discover cures particular to the various sickness entities, together with polycythemia vera, crucial thrombocytopenia, myelofibrosis, and eosinophilic problems, and mastocytosis. distinctive parts of dialogue contain JAK2 inhibitor treatment, hematopoietic stem mobilephone transplantation, and blastic transformation. A invaluable reference for working towards hematologists, this vanguard e-book enriches our realizing of contemporary discoveries and their influence on traditional and investigational treatments.

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Chronic neutrophilic leukemia with an associated V617F JAK2 tyrosine kinase mutation. Haematologica 2005; 90: 1696–7. 79. Kako S, Kanda Y, Sato T, et al. Early relapse of JAK2 V617F-positive chronic neutrophilic leukemia with central nervous system infiltration after unrelated bone marrow transplantation. Am J Hematol 2007; 82: 386–90. Chapter 1 Diagnosis and Classification of the BCR-ABL1 37 80. Elliott MA, Hanson CA, Dewald GW, et al. WHO-defined chronic neutrophilic leukemia: a long-term analysis of 12 cases and a critical review of the literature.

31. Najean Y, Dresch C, Rain JD. The very-long-term course of polycythaemia: a complement to the previously published data of the Polycythaemia Vera Study Group. Br J Haematol 1994; 86: 233–5. 32. Alvarez-Larran A, Bellosillo B, Martinez-Aviles L, et al. Postpolycythaemic myelofibrosis: frequency and risk factors for this complication in 116 patients. Br J Haematol 2009; 146: 504–9. 33. Vannucchi AM, Antonioli E, Guglielmelli P, et al. Clinical profile of homozygous JAK2 617V>F mutation in patients with polycythemia vera or essential thrombocythemia.

70. Steensma DP, Tefferi A. Cytogenetic and molecular genetic aspects of essential thrombocythemia. Acta Haematol 2002; 108: 55–65. 71. Elliott MA, Tefferi A. Thrombosis and haemorrhage in polycythemia vera and essential thrombocythemia. Br J Haematol. 2005; 128: 275–290. 72. Cervantes F, Alvarez-Larran A, Talarn C, Gomez M, Montserrat E. Myelofibrosis with myeloid metaplasia following essential thrombocythaemia: actuarial probability, presenting characteristics and evolution in a series of 195 patients.

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