By David F. Claxton, Paula Marlton (auth.), Emil J. Freireich M.D., Hagop Kantarjian M.D. (eds.)
Leukemia is a malignant disorder which maintains to play a innovative position within the discovery of latest easy wisdom in regards to the malignant method and in regards to the power for controlling those malignant ailments.
Molecular Genetics and treatment of Leukemia offers contributions via best investigators and clinical participants to such themes as chromosome sixteen, chromosome five, the BCL-2 gene, 11q23 breakpoint leukemias, the p-53 suppressor gene and oncogene, hematopoietic stem cells, cytokines, detection of minimum residual sickness in acute lymphoblastic leukemia, autologous marrow transplantation, the retinoblastoma gene, allogeneic bone marrow transplant and chemotherapy of acute lymphoblastic leukemia.
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Example text
Using high-resolution banding techniques, Sq31 has been identified as the most common cytogenetically deleted segment in 91 out of 93 patients with Sq deletion [12]. This segment corresponds to 17Mb of DNA. As shown in figure 1, a unique and striking cluster of genes, which govern normal hematolymphoid growth and differentiation, has been fine mapped to reside within a few mega bases of each other on band Sq31 [13,14]. 3. Molecular delineation of the critical region Is the smallest region of overlap (SRO) common to both the Sq- syndrome and MDS/AML, or is there more than a single critical gene on Sq31?
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