By Kaushik Nag
The one resource to explain the lung surfactant as a fancy membranous approach, this advisor analyzes lung surfactant functionality from the features of molecular biology, biophysics, membrane technology, and floor and interface research and reports the newest simple and scientific concerns in relation to lung disorder and (dys)function.
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Additional resources for Lung Biology in Health & Disease Volume 201 Lung Surfactant Function and Disorder
Sample text
471 Composition, Structure, and Function 1 Lung Surfactant Phospholipid Molecular Species in Health and Disease TONY POSTLE WOLFGANG BERNHARD School of Medicine and Southampton General Hospital, Southampton, UK University of Tu¨bingen, Tu¨bingen, Germany I. II. Introduction Composition of Surfactant Phospholipid Molecular Species in the Adult Lungs III. Molecular Species of Surfactant Phospholipid During Fetal Development IV. Molecular Species of Phospholipid During Postnatal Development V.
450 II. Surfactant Therapy in Neonatal Respiratory Distress Syndrome . . 450 III. Status of Surfactant Therapy for NRDS in Developing Countries . . 450 IV. In Vitro Evaluation of Surfactants . . 451 V. Parameters of Physiological Relevance . . 451 VI. In Vitro Results for Herbal Oil Surfactants for NRDS . . 452 VII. Proposed Mechanism of Action of Herbal Oil Surfactants . . 454 VIII. Surfactant Therapy in Adult Respiratory Distress Syndrome . . 455 IX. Surfactant Inhibition Studies In Vitro .
These surfactants contained essentially only four major PtdCho molecular species other than PC16:0/16:0 and small amounts of polyunsaturated species. As will be discussed later, PC16:0/ 18:2 and PC16:0/18:1 are major components of plasma lipoprotein and inflammatory cell membrane PtdCho, respectively, in addition to being minor components of surfactant. In contrast, PC16:0/14:0 and PC16:0/16:1 are minor components of cell membrane PtdCho and can be regarded as diagnostic for surfactant. This conclusion is supported by metabolic labeling experiments showing identical kinetics for the incorporation of [3H]choline into alveolar PC16:0/14:0, PC16:0/16:1, and PC16:0/16:0 for mouse and perfused rat lungs (17).