By SN Chugh
Diabetes provides a research-based dialogue at the ailment, describing new advances in its administration and therapy. observed through a photograph CD ROM, the booklet starts with the elemental anatomy and body structure of the pancreas and is going directly to research the different sorts of diabetes, prognosis, therapy and attainable issues. A separate bankruptcy considers different elements of diabetes, corresponding to in being pregnant and riding.
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Additional resources for Diabetes
Sample text
The prevalence of diabetes is higher in men than in women but there are more women with diabetes than men. The number of people with diabetes is increasing due to population growth, aging, urbanization and increasing prevalence of obesity and physical inactivity. 1. The top three countries are the same as those identified in 1995. Diabetes is achieving epidemic proportion throughout the world (Fig. 1). 1: List of countries with the highest numbers of estimated cases of diabetes for 2000 and 2030 2000 Ranking 1.
UNIT 2: DIABETES: PREVALENCE, TYPES, CLASSIFICATION 35 Autoimmune insulitis/isletitis is the proposed mechanism in pathogenesis of type 1 DM (Fig. 6). The Fig. 6: Pathogenesis of type 1 DM 36 MINI ATLAS SERIES: DIABETES disease is frequently associated with other autoimmune diseases. More than 90% patients with type 1 DM have antibodies directed against insulin and other beta cell antigens. The histological picture of early islet infiltration by macrophages, CD4 T cells, CD 8 T cells and B cells, hyperexpression of HLA class I and II genes ( HLA-DR, DQ and DP loci) and expression of inflammatory cytokines support the autoimmune destruction of the pancreatic beta cells via cell-mediated and humoral mechanisms.
4. Features (Type 1) (Fig. 4) (Type 2) (Fig. 5) Gene locus Age of onset Onset Body weight Chromosome 6 <30 years Rapid Thin, lean Chromosome 11 >30 years Slow Normal weight or obese Months or years 5. Duration of symptoms 6. Presenting features 7. Ketonuria 8. Complications at diagnosis 9. Family history 10. Plasma insulin 11. Choice of drug 12. Mortality if untreated Weeks Polyuria, polydipsia polyphagia Ketone-prone Absent Present with different complications Ketone-resistant Present (10-20%) Negative Low or absent Insulin High Positive Normal to high Oral antidiabetic Low UNIT 2: DIABETES: PREVALENCE, TYPES, CLASSIFICATION 31 Earlier classification based on the age of onset (juvenile or adult onset) and type of therapy (IDDM and NIDDM) are obsolete nowadays.