By G. Stenman, J. Bullerdiek, S. Bartnitzke, P. Sahlin, E. Röijer, J. Mark (auth.), Prof. Dr. J. Bullerdiek, Dr. S. Bartnitzke (eds.)
Researchers concerned about the cytogenetics and molecular genetics of human tumors will welcome this complete evaluation of the kind of aberrations that chromosome 12 provides in human reliable tumors. The authors learn the results for a cytogenetic subtyping of the tumors concerned and techniques for selecting the molecular adjustments which underlie the karyotypic changes.
The aberrations of chromosome 12 which the booklet bargains with are very widespread chromosomal changes in human tumors occuring in widespread benign mesenchymal tumors, comparable to uterine leiomyomas and lipomas, and in tumors of epithelial starting place, similar to pleomorphic adenomas of the salivary glands.
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Extra info for Chromosome 12 Aberrations in Human Solid Tumors: Cytogenetics and Molecular Genetics
Obviously, it is not known whether the genetic content of these rings is similar in the different tumor types. Finally, various aberrations involving the distal half of the short arm of chromosome 6 have been found not only in lipomas, but also in the leiomyomas and pleomorphic adenomas. References Äman P, Ron D, Mandahl N, Fioretos T, Heim S, Arheden K, Willen H, Rydholm A, Mitelman F (1992) Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;pll). Genes Chrom Cancer 5:278-285 Becher R, Wake N, Gibas Z, Ochi H, Sandberg AA (1984) Chromosome changes in soft tissue sarcomas.
Cancer Geriet Cytogenet 60:170-175 Pan dis N, Heim S, Bardi G, Floderus U-M, Willen H, Mandahl N, Mitelman F (1991) Chromosome analysis of 96 uterine leiomyomas. Cancer Genet Cytogenet 55:11-18 Peulve P, Thomine E, Hemet J (1990) Cytogenetic analysis of a rare case of pediatric myxolipoma. Ann Genet 33:222-224 Sait SNJ, Dal Cin P, Sandberg AA, Leong S, Karakousis C, Rao U, Harris K (1989) Involvement of 6p in benign lipomas. A new cytogenetic entity? Cancer Genet Cytogenet 37:281-283 Sandberg AA (1990) The chromosomes in human cancer and leukemia, 2nd edn.
As generally shown for cancer breakpoints, a significantly nonrandom correlation between the breakpoints and the fragile sites has been observed which most likely can be explained by the fact that the fragile sites as weIl as the breakpoints are predominantly in light G bands. Therefore, when testing only those breakpoints occurring in light G bands, no significant correlation is found. This finding exactly confirms the findings by Sutherland and Simmers (1988) who demonstrated that there is no statistical association between common fragile sites and cancer breakpoints when their prefercntial distribution on light G bands is taken into account.