By Robert D. Goldman, Robert V. Zackroff, Peter M. Steinert (auth.), Robert D. Goldman, Peter M. Steinert (eds.)
Research task on intermediate filaments (IF) has elevated dramatically over the last decade. For the main half, this surge of curiosity is because of their id as ubiquitous materials of the cytoskeleton and karyoskeleton (nuclear matrix) of eukaryotic cells and the truth that we all know little or no concerning their services. In sharp distinction to the opposite significant cytoskeletal platforms, microfilaments and microtubules, IF convey a excessive measure of heterogeneity in regards to their protein subunit composition. certainly, you'll basically surprise on the variety of varied IF polypeptides, their linked proteins (IFAP) and, accordingly, the variety of genes curious about encoding the a number of parts of many of the IF networks present in varied cellphone kinds. The chapters during this e-book reveal how numerous experimental methods involv ing mobile, molecular, biochemical, and immunological equipment were applied to generate information about the constitution and serve as of IF. To this finish, we now have accrued jointly chapters from specialists within the significant fields of IF study. In each one bankruptcy, the authors have mixed experiences of the to be had clinical literature with their very own rules on present and destiny instructions for IF study. The chapters were divided into 5 significant sections that are all for the subcellular association of IF, the molecular constitution of IF, the differential expression of IF genes, descriptions of associ ated proteins focused on the intracellular association of IF, and at last an research of the adjustments noticeable in IF in pathological conditions.
Read Online or Download Cellular and Molecular Biology of Intermediate Filaments PDF
Similar biology books
This ebook used to be written by means of many striking investigators who've spent many years to review diversified points of blood‑tissue barrier functionality. they've got summarized a number of the most up-to-date and engaging improvement of their fields of analysis together with the blood‑brain barrier, the blood‑retinal barrier, the intestine barrier, the blood‑biliary barrier, the blood‑follicle barrier, the blood‑epididymis barrier, the blood‑testis barrier, the tight junction barrier more often than not in addition to boundaries within the girl reproductive tract.
- Biology of the Integument: Invertebrates
- Protocols for Adult Stem Cells
- Pigment Cell Biology. Proceedings of the Fourth Conference on the Biology of Normal and Atypical Pigment Cell Growth
- Treatise on Invertebrate Paleontology - Part S - Echinodermata 1
- Pyrosequencing® Protocols
Extra resources for Cellular and Molecular Biology of Intermediate Filaments
1983, The membrane systems and cytoskeletal elements of mammalian Intermediate (lO-nm) Filaments in Muscle 33 myocardial cells, in: Cell and Muscle Motility, Volume 3 (R. M. Dowben and J. W. ), Plenum Press, New York, pp. 89-155. , 1981, Aortic smooth muscle cells contain vimentin instead of desmin, Proc. Natl. Acad. Sci. USA 78:3020-3024. , 1981, Electron microscopy of vimentin filaments and associated whisker structures in thin sections and freeze-fractures, Bioi. Cell 41: 173- 178. , 1985, Intermediate filament structure: 2.
1976, Depolymerization of F-actin by deoxyibnuclease I, Cell 7:531-542. Holmes, K. , and Choppin, P. , 1968, On the role of microtubules in movement and alignment of nuclei in virus-induced syncytia, J. Cell Bioi. 39:526-542. , Sanger, 1. , 1972, Selected topics in skeletal myogenesis, Cold Spring Harbor Syrnp. Quant. Bioi. 37:549-566. , 1976, Cells, myosins and 100A filaments, in: Cell Motility (R. D. Goldman, R. D. Pollards, and J. L. , Book B, pp. 823-839. , 1987, Site specific phosphorylation induces disassembly of vimentin filaments in vitro, Nature 328:649-652.
6:685. Day, W. , and Gilbert, D. , 1972, X-ray diffraction pattern of axoplasm, Biochim. Biophys. Acta 285:503506. , 1979, Intermediate (skeletin) filaments in heart Purkinje fibers. A correlative morphological and biochemical identification with evidence of a cytoskeletal function, J. Cell Bioi. 80:231-247. Evans, R. , 1984, Peptide mapping of phosphorylated vimentin, J. Bioi. Chem 259:5372-5375. Evans, R. , 1988, Cyclic AMP-dependent protein kinase-induced vimentin filament disassembly involves modification of the N-terminal domain of intermediate filament subunits, FEBS Lett.