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Extra resources for Annual reports in medicinal chemistry. / Volume 9
50/kg of morphine), it has been reported 128*p32 t h a t morphine base sells f o r up t o $2000/kg, t h a t 407. pure heroin sells f o r $20,00O/kg, and t h a t 1-37, pure heroin sells f o r $400,00O/kg on the 'street'. The l a r g e p r o f i t s from heroin production and d i s t r i b u t i o n underline the d i f f i c u l t y i n stopping smuggling of heroin. S. S. S. from abroad each year carrying about 200,000,000 persons through customs. Since t h e d a i l y heroin requirement i s only about 1 2 kg, and considering t h a t a s i n g l e person can r e a d i l y c a r r y $500,000 worth of heroin on one t r i p , the problem of i n t e r d i c t i n g heroin smuggling can be appreciated.
223. 224. 225. 226. 227. 228. 229. 230. 231. 232. N. Narasfmhacharl, J. Avalos, H. F u j i m r l and H. H i m i c h , Biol. P s y c h i a t . , (1972). --. (1914) D. B. E. A. P. M. A. E & ~ Dyer, D. Kichols, D. R u s t e r h o l z and C. Barfknecht, L i f e S c i . , E, 885 (1973). A n g r i s t , B. Shopsin, and S. Cershon, Nature (London), 152 (1971). Uyeno, P s y c h o p h n m c o l o g i a , 381 (1971). Kulkarni, Biol. , 177 (1973). Cooper and G. W a l t e r s , Nature (London), 238. 96 (1972).
W. Robinson, C l i n i c a l Trials J o u r n a l , 2, 3 9, (1972). 53. D . J . Vicary, P. M. Horrocks, J . E. Rees, J , D. Parkes and C . D . Marsden, C l i n i c a l T r i a l s J o u r n a l , l0, 3 (1973). D . J . J e f f e r y , D. M. Brown and P. F. Langley, Xenobiotica, 5 , 169 54. 55. G. Clark and J . Davies, B r i t . J . , 465 (1973). R . C. U r s i l l o and J. A . McCulloch, Arch. I n t . , 197,132 56. 57. 58. E. A. S p i e g e l and H. T . , 2,176 (1969). H. T. Wycis, Confinia Neurol.