By Paul Wassarman
Advances in Developmental Biology used to be introduced as a chain via JAI Press in 1992 with the looks of quantity 1. This sequence is inextricably associated with the significant other sequence, Advances in Developmental Biochemistry , that used to be introduced while. As acknowledged within the Preface to quantity 1: ''Together the 2 sequence will supply annual stories of study issues in developmental biology/biochemistry, written from the views of top investigators in those fields. it truly is meant that every overview draw seriously shape the author's personal learn contributions and point of view. hence, the displays are usually not unavoidably encyclopedic in assurance, nor do they inevitably replicate all opposing perspectives of the subject.'' quantity 2 of the sequence follows those similar directions.
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A . Direct Analysis of Gene Expression . . . . . . . . . . B . Indirect Analysis of Gene Expression . . . . . . . . . . IV. Genes that Escape X Inactivation . . . . . . . . . . . . V. The X Inactivation Process . . . . . . . . . . . . . . VI. The X Inactivation Center and the XISTGene . . . . . . . . . VII. Models for X Chromosome Inactivation . . . . . . . . . . A . Initiation . . . . . . . . . .
References and Notes . . . . . . . . . . . . . . . Advances in Developmental Bidogy Volume 2, pages 37-72 Copyright 8 1993 by JAI Press Inc All rights of reproduction in any form reserved ISBN: 1-55938-582-0 . BROWN and HUNTINGTON F. WILLARD PREFACE X chromosome inactivation is a unique developmental event which results in the cis-limited inactivation of most genes on one of the pair of X chromosomes in mammalian females. The inactive X also becomes heterochromatic, asynchronously replicating, and differentially methylated.
Anat. 174:171-1 84. Smith, C. P. , Williams, P. L.. and Treadgold, S. (1969) The urogenital system. In: Basic Human Embryology, pp. 92-97. Pitman Publishers, London. , Maeda. , and Yamamoto. M. (1991). Schizosaccharomyces pombe stell+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development. Genes Dev. 51990-1999. The Sry Gene and Sex Determination in Mammals 35 Sutcliffe. M. S. (1989). Analysis ofthe testesof H-Y negative XOSxrb mice suggests that the spermatogenesis gene (Spy) acts during the differentiation of the A spermatogonia.